Player | GP | ATT | YDS | TD | YPA | |
|---|---|---|---|---|---|---|
  | Saquon Barkley PHI Eagles | 4 | 91 | 499 | 5 | 5.48 |
  | James Cook BUF Bills | 3 | 53 | 272 | 3 | 5.13 |
  | Derrick Henry BAL Ravens | 2 | 42 | 270 | 3 | 6.43 |
  | Joe Mixon HOU Texans | 2 | 43 | 194 | 2 | 4.51 |
  | Kyren Williams LAR Rams | 2 | 35 | 182 | 0 | 5.2 |
  | Brian Robinson WAS Commanders | 3 | 36 | 129 | 2 | 3.58 |
  | Kareem Hunt KC Chiefs | 3 | 28 | 117 | 2 | 4.18 |
  | Jahmyr Gibbs DET Lions | 1 | 14 | 105 | 2 | 7.5 |
 | Ty Johnson BUF Bills | 3 | 20 | 94 | 0 | 4.7 |
 | Austin Ekeler WAS Commanders | 3 | 22 | 89 | 0 | 4.05 |
  | Josh Jacobs GB Packers | 1 | 18 | 81 | 1 | 4.5 |
 | Will Shipley PHI Eagles | 4 | 4 | 77 | 1 | 19.25 |
  | Bucky Irving TB Buccaneers | 1 | 17 | 77 | 0 | 4.53 |
 | Justice Hill BAL Ravens | 2 | 12 | 62 | 0 | 5.17 |
  | Aaron Jones MIN Vikings | 1 | 13 | 48 | 0 | 3.69 |
 | Kenneth Gainwell PHI Eagles | 4 | 13 | 42 | 0 | 3.23 |
 | Cam Akers MIN Vikings | 1 | 5 | 39 | 0 | 7.8 |
 | Isiah Pacheco KC Chiefs | 3 | 13 | 37 | 0 | 2.85 |
 | Ray Davis BUF Bills | 3 | 7 | 36 | 1 | 5.14 |
  | Javonte Williams DEN Broncos | 1 | 7 | 29 | 0 | 4.14 |
 | David Montgomery DET Lions | 1 | 7 | 28 | 0 | 4 |
  | J.K. Dobbins LAC Chargers | 1 | 9 | 26 | 0 | 2.89 |
 | Dameon Pierce HOU Texans | 2 | 6 | 25 | 0 | 4.17 |
 | Gus Edwards LAC Chargers | 1 | 7 | 22 | 0 | 3.14 |
  | Najee Harris PIT Steelers | 1 | 6 | 17 | 0 | 2.83 |
 | Dare Ogunbowale HOU Texans | 2 | 2 | 14 | 0 | 7 |
 | Jeremy McNichols WAS Commanders | 3 | 5 | 9 | 1 | 1.8 |
 | Samaje Perine KC Chiefs | 3 | 1 | 8 | 0 | 8 |
 | Ronnie Rivers LAR Rams | 2 | 3 | 8 | 0 | 2.67 |
 | Tyler Badie DEN Broncos | 1 | 2 | 8 | 0 | 4 |
 | Emanuel Wilson GB Packers | 1 | 3 | 6 | 0 | 2 |
 | Jaylen Warren PIT Steelers | 1 | 2 | 6 | 0 | 3 |
 | Hassan Haskins LAC Chargers | 1 | 1 | 5 | 0 | 5 |
 | Rachaad White TB Buccaneers | 1 | 1 | 1 | 0 | 1 |