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EXP
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49ers Depth Chart

Quarterback
Brock Purdy thumbnail
Brock Purdy
#13
Mac Jones thumbnail
Mac Jones
#10
Carter Bradley thumbnail
Carter Bradley
#17
Kurtis Rourke thumbnail
Kurtis Rourke
#4
Running Back
Christian McCaffrey thumbnail
Christian McCaffrey
#23
Isaac Guerendo thumbnail
Isaac Guerendo
#31
Jordan James thumbnail
Jordan James
#29
Ameer Abdullah thumbnail
Ameer Abdullah
#38
Kyle Juszczyk thumbnail
Kyle Juszczyk
#44
Patrick Taylor thumbnail
Patrick Taylor
#32
Corey Kiner thumbnail
Corey Kiner
#49
Wide Receiver
Jauan Jennings thumbnail
Jauan Jennings
#15
Jacob Cowing thumbnail
Jacob Cowing
#19
Robbie Chosen thumbnail
Robbie Chosen
#3
Terique Owens thumbnail
Terique Owens
#83
Equanimeous St. Brown thumbnail
Equanimeous St. Brown
#7
Isaiah Hodgins thumbnail
Isaiah Hodgins
#18
Junior Bergen thumbnail
Junior Bergen
#86
Ricky Pearsall thumbnail
Ricky Pearsall
#1
Jordan Watkins thumbnail
Jordan Watkins
#17
Brandon Aiyuk thumbnail
Brandon Aiyuk
#11
Russell Gage thumbnail
Russell Gage
#84
Demarcus Robinson thumbnail
Demarcus Robinson
#5

San Francisco 49ers

NFC West Division Standings

TEAM
W
L
T
PCT
T1Los Angeles Rams Logo
Los Angeles
Rams
10700.588
T1Seattle Seahawks Logo
Seattle
Seahawks
10700.588
3Arizona Cardinals Logo
Arizona
Cardinals
8900.471
4San Francisco 49ers Logo
San Francisco
49ers
61100.353
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Isaac Guerendo News

Player Performance Chat for 8/16/2025 vs LV1 d
Isaac Guerendo (shoulder) to miss a few weeks5 d
sad34
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meme_throw_up11
+4
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Isaac Guerendo - Out for a few weeks5 d
sad18
meme_stare8
meme_throw_up7
+4
5
Isaac Guerendo suffers apparent shoulder/arm injury Saturday6 d
meme_soldier31
sad20
meme_stare11
+8
8
Isaac Guerendo - Exits practice with apparent injury7 d
sad46
meme_stare26
meme_crying_jordan22
+8
18
Player Performance Chat for 8/9/2025 vs DEN8 d
Isaac Guerendo 2025 Season Outlook26 d
fire15
eyes8
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Player Performance Chat for 9/7/2025 vs SEA26 d
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Isaac Guerendo 2025 Fantasy Outlook

Few running backs in NFL history come close to the raw athletic ability of Guerendo, who at 6 feet, 220 pounds has blazing speed (4.33 40) and elite explosiveness (41.5-inch vertical, 129-inch broad jump). It's such a shame, then, that Guerendo may be one of the most fragile RB prospects in recent memory. He had horrendous injury luck for all but one of the past six years, at one point in college suffering hamstring tears two years in a row before suffering a Lisfranc injury the third year. In his 2024 rookie year, Guerendo missed time at various points with hamstring, groin and foot injuries, and in the season finale against Arizona he suffered an MCL sprain and ankle sprain in the same leg. As if to make all of this more tormenting, Guerendo has real skill in addition to his ridiculous athleticism - he runs with power and is likely an above-average receiver - but it just isn't clear he can ever stay healthy to realize his upside. For now, Guerendo will remain a boom-or-bust backup to Christian McCaffrey, after the 49ers traded Jordan Mason to Minnesota in the offseason.

SF LogoIsaac Guerendo Image

Isaac Guerendo

INJ: Questionable
AGE
25
HEIGHT
6'0"
WEIGHT
221 lbs
EXP
1
COLLEGE
Louisville
Player Rankings
54%Rostered
4%Started
RB
49ers #31
SF LogoIsaac Guerendo Image
Isaac
Guerendo
Louisville • 1 YRS EXP.
INJ: Questionable
SF Logo
49ers
#31
•
RB
6'0"
221
25
Rostered
54
%
Started
4
%

Isaac Guerendo Game Log

RushingReceiving
WeekOppResultCARYDSTDAVGLNGRECTGTYDSAVGTDLNG
18vsArizona Cardinals Logo
ARI
L24-472502.530000.000
17@Detroit Lions Logo
DET
L34-4093403.811446516.3040
15@Los Angeles Rams Logo
LAR
L6-12165703.61644184.5010
14@Chicago Bears Logo
CHI
W38-13157825.230225025.0027
13vsBuffalo Bills Logo
BUF
L10-3541914.81511-3-3.00-3
12vsGreen Bay Packers Logo
GB
L10-380000.000000.000
11@Seattle Seahawks Logo
SEA
L17-200000.000000.000
10vsTampa Bay Buccaneers Logo
TB
W23-201000.000000.000
8@Dallas Cowboys Logo
DAL
W30-24148516.11934175.7012
7@Kansas City Chiefs Logo
KC
L18-281202.021155.005
6vsSeattle Seahawks Logo
SEA
W36-24109909.9760000.000
5@Arizona Cardinals Logo
ARI
L23-2452204.450000.000
4@New England Patriots Logo
NE
W30-131000.000000.000
3vsLos Angeles Rams Logo
LAR
L24-2751903.860000.000
2vsMinnesota Vikings Logo
MIN
L17-231000.000000.000
1@New York Jets Logo
NYJ
W32-190000.000000.000

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