49ers RB Christian McCaffrey is targeting an early November return as he rehabs from Achilles tendinitis, per @RapSheet

Joe Flacco is in the game at QB for the Colts for an injured Anthony Richardson

Rams WR Cooper Kupp (ankle) will miss at least the next 2 weeks, and Puka Nacua (knee) is out at least another month, per @JayGlazer

Steelers QB Russell Wilson is inactive for the 4th week in a row, per @AdamSchefter Will Russ ever start for the Steelers?

Keenan Allen (heel) is active today

Chris Olave and Alvin Kamara will both be active for the Saints today, per @nick_underhill

Texans RB Joe Mixon will be OUT today vs the Jaguars due to his ankle injury, per @Schultz_Report

Buccaneers RBs Rachaad White and Bucky Irving, both listened as questionable, are expected to play today, per @AdamSchefter

49ers WR Deebo Samuel plans to play Sunday vs the Patriots, per @Schultz_Report